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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Wee1-like protein kinase | ||
| Ligand | BDBM50164155 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_304894 (CHEMBL829373) | ||
| IC50 | 3400±n/a nM | ||
| Citation |  Palmer, BD; Smaill, JB; Rewcastle, GW; Dobrusin, EM; Kraker, A; Moore, CW; Steinkampf, RW; Denny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Wee1-like protein kinase | |||
| Name: | Wee1-like protein kinase | ||
| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 71599.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1445054 | ||
| Residue: | 646 | ||
| Sequence: |
| ||
| BDBM50164155 | |||
| n/a | |||
| Name | BDBM50164155 | ||
| Synonyms: | 6-(2-Chloro-6-methoxy-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL181282 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H17ClN4O2 | ||
| Mol. Mass. | 392.838 | ||
| SMILES | COc1cccc(Cl)c1-c1cc2cnc(Nc3ccccc3)nc2n(C)c1=O |(6.38,-1.83,;5.04,-1.08,;5.02,.46,;6.35,1.25,;6.35,2.79,;5,3.55,;3.69,2.77,;2.34,3.52,;3.69,1.24,;2.36,.46,;1.03,1.23,;-.3,.44,;-1.63,1.21,;-2.96,.44,;-2.96,-1.1,;-4.29,-1.87,;-5.62,-1.1,;-5.62,.44,;-6.95,1.21,;-8.28,.41,;-8.28,-1.13,;-6.95,-1.9,;-1.63,-1.87,;-.3,-1.1,;1.06,-1.87,;1.06,-3.41,;2.39,-1.08,;3.72,-1.85,)| | ||
| Structure | 
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