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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Wee1-like protein kinase | ||
| Ligand | BDBM50164161 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_304894 (CHEMBL829373) | ||
| IC50 | 410±n/a nM | ||
| Citation |  Palmer, BD; Smaill, JB; Rewcastle, GW; Dobrusin, EM; Kraker, A; Moore, CW; Steinkampf, RW; Denny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Wee1-like protein kinase | |||
| Name: | Wee1-like protein kinase | ||
| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 71599.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1445054 | ||
| Residue: | 646 | ||
| Sequence: |
| ||
| BDBM50164161 | |||
| n/a | |||
| Name | BDBM50164161 | ||
| Synonyms: | 6-(2,6-Dibromo-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL362402 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H14Br2N4O | ||
| Mol. Mass. | 486.159 | ||
| SMILES | Cn1c2nc(Nc3ccccc3)ncc2cc(-c2c(Br)cccc2Br)c1=O |(1.29,-3.48,;1.29,-1.94,;-.06,-1.17,;-1.39,-1.94,;-2.72,-1.17,;-4.05,-1.94,;-5.38,-1.17,;-5.38,.37,;-6.71,1.14,;-8.04,.34,;-8.03,-1.2,;-6.71,-1.97,;-2.72,.37,;-1.39,1.14,;-.06,.37,;1.27,1.16,;2.61,.39,;3.93,1.16,;5.26,.4,;5.28,-1.15,;6.59,1.18,;6.59,2.72,;5.23,3.48,;3.93,2.7,;2.57,3.45,;2.62,-1.15,;3.95,-1.92,)| | ||
| Structure | 
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