Reaction Details | |||
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Target | Wee1-like protein kinase | ||
Ligand | BDBM50164110 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_304894 (CHEMBL829373) | ||
IC50 | 33000±n/a nM | ||
Citation | Palmer, BD; Smaill, JB; Rewcastle, GW; Dobrusin, EM; Kraker, A; Moore, CW; Steinkampf, RW; Denny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Wee1-like protein kinase | |||
Name: | Wee1-like protein kinase | ||
Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
Type: | PROTEIN | ||
Mol. Mass.: | 71599.12 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1445054 | ||
Residue: | 646 | ||
Sequence: |
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BDBM50164110 | |||
n/a | |||
Name | BDBM50164110 | ||
Synonyms: | 6-(3,5-Dimethoxy-2,6-dimethyl-phenyl)-8-methyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL359824 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H24N4O3 | ||
Mol. Mass. | 416.4724 | ||
SMILES | COc1cc(OC)c(C)c(c1C)-c1cc2cnc(Nc3ccccc3)nc2n(C)c1=O |(5.67,5.48,;4.32,4.71,;4.36,3.15,;5.7,2.4,;5.7,.86,;7.05,.11,;7.05,-1.45,;4.37,.09,;4.37,-1.45,;3.04,.86,;3.02,2.37,;1.69,3.14,;1.71,.06,;.38,.83,;-.93,.05,;-2.28,.83,;-3.61,.04,;-3.61,-1.5,;-4.94,-2.27,;-6.28,-1.52,;-6.27,.04,;-7.62,.79,;-8.94,.04,;-8.93,-1.52,;-7.6,-2.27,;-2.28,-2.27,;-.93,-1.49,;.4,-2.26,;.4,-3.8,;1.71,-1.49,;3.06,-2.25,)| | ||
Structure |