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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Wee1-like protein kinase | ||
| Ligand | BDBM50164162 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_304894 (CHEMBL829373) | ||
| IC50 | 990±n/a nM | ||
| Citation |  Palmer, BD; Smaill, JB; Rewcastle, GW; Dobrusin, EM; Kraker, A; Moore, CW; Steinkampf, RW; Denny, WA Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorg Med Chem Lett15:1931-5 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Wee1-like protein kinase | |||
| Name: | Wee1-like protein kinase | ||
| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 71599.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1445054 | ||
| Residue: | 646 | ||
| Sequence: |
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| BDBM50164162 | |||
| n/a | |||
| Name | BDBM50164162 | ||
| Synonyms: | 2-[4-(2-Diethylamino-ethoxy)-phenylamino]-6-(2,6-dimethyl-phenyl)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL181095 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H33N5O2 | ||
| Mol. Mass. | 471.5939 | ||
| SMILES | CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(C)cccc4C)c(=O)n(C)c3n2)cc1 |(-5.69,4.01,;-7.02,4.78,;-8.35,4.01,;-9.7,4.78,;-11.03,4.01,;-8.35,2.47,;-7.02,1.7,;-7.02,.16,;-5.67,-.61,;-5.66,-2.15,;-4.33,-2.92,;-3.01,-2.13,;-1.67,-2.9,;-.34,-2.13,;-.34,-.59,;.99,.19,;2.32,-.59,;3.65,.2,;4.98,-.57,;6.31,.2,;6.31,1.74,;4.95,2.5,;7.61,2.51,;8.97,1.77,;8.97,.23,;7.64,-.56,;7.65,-2.1,;5,-2.11,;6.33,-2.88,;3.66,-2.9,;3.66,-4.44,;2.32,-2.12,;.99,-2.9,;-3,-.59,;-4.33,.18,)| | ||
| Structure | 
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