| Reaction Details |
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 | Report a problem with these data |
| Target | Melanin-concentrating hormone receptor 2 |
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| Ligand | BDBM50164248 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302592 (CHEMBL839552) |
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| Ki | >3000±n/a nM |
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| Citation |  McBriar, MD; Guzik, H; Xu, R; Paruchova, J; Li, S; Palani, A; Clader, JW; Greenlee, WJ; Hawes, BE; Kowalski, TJ; O'Neill, K; Spar, B; Weig, B Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics. J Med Chem48:2274-7 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanin-concentrating hormone receptor 2 |
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| Name: | Melanin-concentrating hormone receptor 2 |
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| Synonyms: | GPR145 | MCHR2 | MCHR2_HUMAN | Melanin Concentrating Hormone 2 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 2 | SLT |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38862.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Melanin Concentrating Hormone 2 GPR145 HUMAN::Q969V1 |
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| Residue: | 340 |
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| Sequence: | MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTII
RSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFAC
SAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDG
VESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPS
VPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSS
INPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
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| BDBM50164248 |
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| n/a |
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| Name | BDBM50164248 |
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| Synonyms: | 3-(3-Chloro-4-fluoro-phenyl)-1-[(3R,6S)-6-(3-cyano-phenyl)-bicyclo[4.1.0]hept-3-yl]-1-[2-((R)-3-hydroxy-pyrrolidin-1-yl)-ethyl]-urea | 3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-((R)-3-hydroxypyrrolidin-1-yl)ethyl)urea | CHEMBL193260 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H30ClFN4O2 |
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| Mol. Mass. | 497.004 |
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| SMILES | O[C@@H]1CCN(CCN([C@@H]2CC[C@@]3(CC3C2)c2cccc(c2)C#N)C(=O)Nc2ccc(F)c(Cl)c2)C1 |
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| Structure | 
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