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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Melanin-concentrating hormone receptor 1 | ||
| Ligand | BDBM50164251 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_302591 (CHEMBL839551) | ||
| Ki | >3000±n/a nM | ||
| Citation |  McBriar, MD; Guzik, H; Xu, R; Paruchova, J; Li, S; Palani, A; Clader, JW; Greenlee, WJ; Hawes, BE; Kowalski, TJ; O'Neill, K; Spar, B; Weig, B Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics. J Med Chem48:2274-7 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Melanin-concentrating hormone receptor 1 | |||
| Name: | Melanin-concentrating hormone receptor 1 | ||
| Synonyms: | G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 45976.27 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays. | ||
| Residue: | 422 | ||
| Sequence: |
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| BDBM50164251 | |||
| n/a | |||
| Name | BDBM50164251 | ||
| Synonyms: | 1-[4-(3-Cyano-phenyl)-4-methyl-cyclohexyl]-3-(4-fluoro-3-trifluoromethyl-phenyl)-1-[2-((R)-3-hydroxy-pyrrolidin-1-yl)-ethyl]-urea | CHEMBL370733 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H32F4N4O2 | ||
| Mol. Mass. | 532.5729 | ||
| SMILES | C[C@]1(CC[C@@H](CC1)N(CCN1CC[C@@H](O)C1)C(=O)Nc1ccc(F)c(c1)C(F)(F)F)c1cccc(c1)C#N |wU:4.7,13.14,wD:1.0,(-1.35,-6.17,;-1.35,-4.63,;,-5.4,;1.33,-4.63,;1.33,-3.09,;,-2.32,;-1.35,-3.09,;2.67,-2.31,;4.01,-3.08,;4.01,-4.63,;5.34,-5.4,;6.68,-4.63,;7.82,-5.67,;7.19,-7.05,;7.96,-8.41,;5.67,-6.91,;2.67,-.75,;1.34,.02,;4,.02,;4,1.56,;2.67,2.33,;2.67,3.89,;4,4.64,;4,6.18,;5.34,3.89,;5.34,2.33,;6.68,4.66,;8.03,5.45,;7.47,3.31,;5.9,6.01,;-2.68,-5.4,;-4.01,-4.63,;-5.34,-5.4,;-5.34,-6.94,;-4.01,-7.71,;-2.68,-6.94,;-4.01,-9.25,;-4.01,-10.79,)| | ||
| Structure | 
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