Reaction Details |
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Target | Heparanase |
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Ligand | BDBM50165637 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_305497 (CHEMBL831099) |
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IC50 | 3000±n/a nM |
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Citation | Courtney, SM; Hay, PA; Buck, RT; Colville, CS; Phillips, DJ; Scopes, DI; Pollard, FC; Page, MJ; Bennett, JM; Hircock, ML; McKenzie, EA; Bhaman, M; Felix, R; Stubberfield, CR; Turner, PR Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivatives: novel classes of heparanase inhibitor. Bioorg Med Chem Lett15:2295-9 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Heparanase |
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Name: | Heparanase |
Synonyms: | Endo-glucoronidase | HEP | HPA | HPA1 | HPR1 | HPSE | HPSE1 | HPSE_HUMAN | HSE1 | Heparanase 50 kDa subunit | Heparanase 8 kDa subunit | Heparanase-1 |
Type: | PROTEIN |
Mol. Mass.: | 61167.67 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_327900 |
Residue: | 543 |
Sequence: | MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVT
IDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQS
QVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCS
GLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGS
QLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYL
NGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFA
AGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLM
ASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLL
RPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVA
ACI
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BDBM50165637 |
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n/a |
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Name | BDBM50165637 |
Synonyms: | (2-{3-Fluoro-4-[3-((E)-4-methoxy-phenyl)-acryloylamino]-phenyl}-benzooxazol-5-yl)-acetic acid | 2-(2-(3-fluoro-4-(3-(4-methoxyphenyl)acrylamido)phenyl)benzo[d]oxazol-5-yl)acetic acid | CHEMBL425734 |
Type | Small organic molecule |
Emp. Form. | C25H19FN2O5 |
Mol. Mass. | 446.4272 |
SMILES | COc1ccc(\C=C\C(=O)Nc2ccc(cc2F)-c2nc3cc(CC(O)=O)ccc3o2)cc1 |
Structure |
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