| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50165671 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305683 (CHEMBL828055) |
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| IC50 | 10000±n/a nM |
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| Citation |  Rossello, A; Nuti, E; Catalani, MP; Carelli, P; Orlandini, E; Rapposelli, S; Tuccinardi, T; Atkinson, SJ; Murphy, G; Balsamo, A A new development of matrix metalloproteinase inhibitors: twin hydroxamic acids as potent inhibitors of MMPs. Bioorg Med Chem Lett15:2311-4 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50165671 |
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| n/a |
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| Name | BDBM50165671 |
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| Synonyms: | CHEMBL196647 | N-{(R)-3-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-3-hydroxycarbamoyl-propyl}-N'-[3-[(biphenyl-4-sulfonyl)-isopropoxy-amino]-3-((R)-hydroxycarbamoyl)-propyl]-isophthalamide |
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| Type | Small organic molecule |
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| Emp. Form. | C46H52N6O12S2 |
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| Mol. Mass. | 945.068 |
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| SMILES | CC(C)ON([C@H](CCNC(=O)c1cccc(c1)C(=O)NCC[C@@H](N(OC(C)C)S(=O)(=O)c1ccc(cc1)-c1ccccc1)C(=O)NO)C(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccccc1 |
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| Structure | 
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