| Reaction Details |
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 | Report a problem with these data |
| Target | Excitatory amino acid transporter 2 |
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| Ligand | BDBM50592916 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2206399 (CHEMBL5119107) |
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| EC50 | 11±n/a nM |
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| Citation |  Abram, M; Jakubiec, M; Reeb, K; Cheng, MH; Gedschold, R; Rapacz, A; Mogilski, S; Soca?a, K; Nieoczym, D; Szafarz, M; Latacz, G; Szulczyk, B; Kalinowska-T?u?cik, J; Gawel, K; Esguerra, CV; Wyska, E; Müller, CE; Bahar, I; Fontana, ACK; Wla?, P; Kami?ski, RM; Kami?ski, K Discovery of ( J Med Chem65:11703-11725 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Excitatory amino acid transporter 2 |
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| Name: | Excitatory amino acid transporter 2 |
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| Synonyms: | EAA2_HUMAN | EAAT2 | GLT1 | Glutamate/aspartate transporter II | SLC1A2 | Sodium-dependent glutamate/aspartate transporter 2 | Solute carrier family 1 member 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 62103.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Excitatory Amino Acid EAAT2 0 0::P43004 |
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| Residue: | 574 |
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| Sequence: | MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVC
GGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRA
MVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENL
VQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMVIKKGLEFKDGM
NVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKI
IAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALG
TASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVL
DGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTS
VNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRESNSNQCVYA
AHNSVIVDECKVTLAANGKSADCSVEEEPWKREK
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| BDBM50592916 |
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| n/a |
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| Name | BDBM50592916 |
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| Synonyms: | CHEMBL5206486 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H16N2O3 |
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| Mol. Mass. | 260.2884 |
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| SMILES | C[C@@H](N1C(=O)CCC1=O)C(=O)NCc1ccccc1 |r| |
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| Structure | 
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