| Reaction Details |
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 | Report a problem with these data |
| Target | Ephrin type-B receptor 2 |
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| Ligand | BDBM50111603 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_304919 (CHEMBL827811) |
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| IC50 | 27500±n/a nM |
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| Citation |  Toledo-Sherman, L; Deretey, E; Slon-Usakiewicz, JJ; Ng, W; Dai, JR; Foster, JE; Redden, PR; Uger, MD; Liao, LC; Pasternak, A; Reid, N Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 2. Identification of small-molecule inhibitors via coupling with virtual screening. J Med Chem48:3221-30 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ephrin type-B receptor 2 |
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| Name: | Ephrin type-B receptor 2 |
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| Synonyms: | DRT | Developmentally-regulated Eph-related tyrosine kinase | ELK-related tyrosine kinase | EPH tyrosine kinase 3 | EPH-like kinase 5 | EPHB2 | EPHB2_HUMAN | EPHT3 | EPTH3 | ERK | Ephrin receptor | HEK5 | TYRO5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 117491.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1476221 |
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| Residue: | 1055 |
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| Sequence: | MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQ
VCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADF
DSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLY
CNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGTFKANQGDEACTHCPINSRTTSEGA
TNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNETSLMLEWTPPRDSGGREDLVYNI
ICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPF
SPQFASVNITTNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSE
YNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAEYQTSIQEK
LPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPF
TYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYT
EKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTV
IQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTY
TSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIE
QDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGI
NLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTL
AGHQKKILNSIQVMRAQMNQIQSVEGQPLARRPRATGRTKRCQPRDVTKKTCNSNDGKKK
GMGKKKTDPGRGREIQGIFFKEDSHKESNDCSCGG
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| BDBM50111603 |
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| n/a |
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| Name | BDBM50111603 |
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| Synonyms: | 3-(4-(dimethylamino)benzylidene)indolin-2-one | 3-(4-Dimethylamino-benzylidene)-1,3-dihydro-indol-2-one | 3-[1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one | CHEMBL296455 | SU-4312 | US11111252, Compound DMBI | US9422297, DMBI |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16N2O |
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| Mol. Mass. | 264.3217 |
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| SMILES | CN(C)c1ccc(\C=C2\C(=O)Nc3ccccc23)cc1 |
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| Structure | 
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