| Reaction Details |
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 | Report a problem with these data |
| Target | Ephrin type-B receptor 2 |
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| Ligand | BDBM3570 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_304919 (CHEMBL827811) |
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| IC50 | 22000±n/a nM |
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| Citation |  Toledo-Sherman, L; Deretey, E; Slon-Usakiewicz, JJ; Ng, W; Dai, JR; Foster, JE; Redden, PR; Uger, MD; Liao, LC; Pasternak, A; Reid, N Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 2. Identification of small-molecule inhibitors via coupling with virtual screening. J Med Chem48:3221-30 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ephrin type-B receptor 2 |
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| Name: | Ephrin type-B receptor 2 |
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| Synonyms: | DRT | Developmentally-regulated Eph-related tyrosine kinase | ELK-related tyrosine kinase | EPH tyrosine kinase 3 | EPH-like kinase 5 | EPHB2 | EPHB2_HUMAN | EPHT3 | EPTH3 | ERK | Ephrin receptor | HEK5 | TYRO5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 117491.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1476221 |
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| Residue: | 1055 |
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| Sequence: | MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQ
VCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADF
DSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLY
CNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGTFKANQGDEACTHCPINSRTTSEGA
TNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNETSLMLEWTPPRDSGGREDLVYNI
ICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPF
SPQFASVNITTNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSE
YNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAEYQTSIQEK
LPLIIGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPF
TYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYT
EKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTV
IQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTY
TSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIE
QDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGI
NLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTL
AGHQKKILNSIQVMRAQMNQIQSVEGQPLARRPRATGRTKRCQPRDVTKKTCNSNDGKKK
GMGKKKTDPGRGREIQGIFFKEDSHKESNDCSCGG
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| BDBM3570 |
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| n/a |
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| Name | BDBM3570 |
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| Synonyms: | 8-[(3-Bromophenyl)amino]-1H-imidazo[4,5-g]quinazoline | Anilinopyrimidine deriv. 7a | CHEMBL66031 | Imidazoquinazoline deriv. 8 | N-(3-bromophenyl)-1H-imidazo[4,5-g]quinazolin-8-amine |
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| Type | Small organic molecule |
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| Emp. Form. | C15H10BrN5 |
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| Mol. Mass. | 340.177 |
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| SMILES | Brc1cccc(Nc2ncnc3cc4nc[nH]c4cc23)c1 |
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| Structure | 
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