| Reaction Details |
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 | Report a problem with these data |
| Target | RNA-directed RNA polymerase |
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| Ligand | BDBM50166382 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305065 (CHEMBL832697) |
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| IC50 | 4000±n/a nM |
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| Citation |  Pfefferkorn, JA; Greene, ML; Nugent, RA; Gross, RJ; Mitchell, MA; Finzel, BC; Harris, MS; Wells, PA; Shelly, JA; Anstadt, RA; Kilkuskie, RE; Kopta, LA; Schwende, FJ Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid. Bioorg Med Chem Lett15:2481-6 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RNA-directed RNA polymerase |
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| Name: | RNA-directed RNA polymerase |
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| Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
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| Type: | Protein |
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| Mol. Mass.: | 25173.95 |
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| Organism: | Hepatitis C virus |
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| Description: | Q8JXU8 |
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| Residue: | 229 |
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| Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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| BDBM50166382 |
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| n/a |
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| Name | BDBM50166382 |
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| Synonyms: | (Z)-2-Benzoylamino-3-[5-(2-trifluoromethoxy-phenyl)-furan-2-yl]-acrylic acid | CHEMBL194116 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H14F3NO5 |
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| Mol. Mass. | 417.3348 |
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| SMILES | OC(=O)C(\NC(=O)c1ccccc1)=C\c1ccc(o1)-c1ccccc1OC(F)(F)F |
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| Structure | 
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