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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Alpha-2A adrenergic receptor | ||
| Ligand | BDBM50166565 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_306656 (CHEMBL831429) | ||
| IC50 | 57±n/a nM | ||
| Citation |  Kanuma, K; Omodera, K; Nishiguchi, M; Funakoshi, T; Chaki, S; Semple, G; Tran, TA; Kramer, B; Hsu, D; Casper, M; Thomsen, B; Beeley, N; Sekiguchi, Y Discovery of 4-(dimethylamino)quinazolines as potent and selective antagonists for the melanin-concentrating hormone receptor 1. Bioorg Med Chem Lett15:2565-9 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Alpha-2A adrenergic receptor | |||
| Name: | Alpha-2A adrenergic receptor | ||
| Synonyms: | ADA2A_HUMAN | ADRA2A | ADRA2R | ADRAR | Adrenergic alpha2A | Adrenergic receptor alpha | Alpha-2 adrenergic receptor subtype C10 | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | alpha-2A adrenergic receptor [Homo sapiens] | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 48979.91 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P08913 | ||
| Residue: | 465 | ||
| Sequence: |
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| BDBM50166565 | |||
| n/a | |||
| Name | BDBM50166565 | ||
| Synonyms: | 4-Bromo-N-[4-(quinazolin-2-ylamino)-cyclohexyl]-2-trifluoromethoxy-benzenesulfonamide | CHEMBL195346 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H20BrF3N4O3S | ||
| Mol. Mass. | 545.373 | ||
| SMILES | FC(F)(F)Oc1cc(Br)ccc1S(=O)(=O)NC1CCC(CC1)Nc1ncc2ccccc2n1 |(8.56,3.94,;7.02,3.94,;7.01,5.48,;5.48,3.94,;7.07,2.4,;8.42,1.67,;9.73,2.47,;11.08,1.74,;12.4,2.56,;11.11,.2,;9.81,-.61,;8.45,.13,;7.15,-.68,;6.05,.41,;7.92,-2.01,;5.82,-1.45,;4.49,-.68,;3.15,-1.45,;1.82,-.68,;1.83,.86,;3.16,1.63,;4.49,.86,;.5,1.63,;-.82,.88,;-.83,-.68,;-2.19,-1.45,;-3.52,-.66,;-4.85,-1.43,;-6.18,-.66,;-6.18,.88,;-4.85,1.65,;-3.52,.88,;-2.16,1.65,)| | ||
| Structure | 
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