Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Alpha-2A adrenergic receptor | ||
Ligand | BDBM50166555 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_306656 (CHEMBL831429) | ||
IC50 | 7.7±n/a nM | ||
Citation | Kanuma, K; Omodera, K; Nishiguchi, M; Funakoshi, T; Chaki, S; Semple, G; Tran, TA; Kramer, B; Hsu, D; Casper, M; Thomsen, B; Beeley, N; Sekiguchi, Y Discovery of 4-(dimethylamino)quinazolines as potent and selective antagonists for the melanin-concentrating hormone receptor 1. Bioorg Med Chem Lett15:2565-9 (2005) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Alpha-2A adrenergic receptor | |||
Name: | Alpha-2A adrenergic receptor | ||
Synonyms: | ADA2A_HUMAN | ADRA2A | ADRA2R | ADRAR | Adrenergic alpha2A | Adrenergic receptor alpha | Alpha-2 adrenergic receptor subtype C10 | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | alpha-2A adrenergic receptor [Homo sapiens] | ||
Type: | Enzyme | ||
Mol. Mass.: | 48979.91 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P08913 | ||
Residue: | 465 | ||
Sequence: |
| ||
BDBM50166555 | |||
n/a | |||
Name | BDBM50166555 | ||
Synonyms: | 4-Bromo-N-{4-[(4-dimethylamino-quinazolin-2-ylamino)-methyl]-cyclohexylmethyl}-2-trifluoromethoxy-benzenesulfonamide | CHEMBL193438 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H29BrF3N5O3S | ||
Mol. Mass. | 616.494 | ||
SMILES | CN(C)c1nc(NCC2CCC(CNS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12 |(-1.86,4.64,;-3.12,3.75,;-4.52,4.4,;-3.12,2.21,;-1.77,1.44,;-1.75,-.12,;-.44,-.89,;.91,-.12,;2.24,-.89,;3.57,-.12,;4.9,-.91,;4.88,-2.45,;6.21,-3.23,;7.56,-2.46,;8.89,-3.24,;7.78,-4.32,;9.64,-1.9,;10.2,-4.04,;11.55,-3.32,;12.86,-4.11,;12.82,-5.65,;14.12,-6.47,;11.46,-6.39,;10.16,-5.58,;8.8,-6.32,;8.76,-7.86,;7.22,-7.85,;10.3,-7.86,;8.75,-9.4,;3.55,-3.2,;2.22,-2.43,;-3.1,-.89,;-4.45,-.12,;-5.78,-.89,;-7.11,-.12,;-7.11,1.42,;-5.78,2.19,;-4.45,1.42,)| | ||
Structure |