| Reaction Details |
|---|
 | Report a problem with these data |
| Target | G protein-activated inward rectifier potassium channel 4 |
|---|
| Ligand | BDBM50593371 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2208083 (CHEMBL5121032) |
|---|
| EC50 | 720±n/a nM |
|---|
| Citation |  Sharma, S; Lesiak, L; Aretz, CD; Du, Y; Kumar, S; Gautam, N; Alnouti, Y; Dhuria, NV; Chhonker, YS; Weaver, CD; Hopkins, CR Discovery, synthesis and biological characterization of a series of RSC Med Chem12:1366-1373 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| G protein-activated inward rectifier potassium channel 4 |
|---|
| Name: | G protein-activated inward rectifier potassium channel 4 |
|---|
| Synonyms: | CIR | Cardiac inward rectifier | GIRK-4 | GIRK4 | Heart KATP channel | IRK-4 | Inward rectifier K(+) channel Kir3.4 | KATP-1 | KCNJ5 | KCNJ5_HUMAN | Potassium channel, inwardly rectifying subfamily J member 5 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 47658.06 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_107914 |
|---|
| Residue: | 419 |
|---|
| Sequence: | MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKC
NVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDH
VGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNA
FMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIK
SRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFE
VVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTP
SCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV
|
|
|
|---|
| BDBM50593371 |
|---|
| n/a |
|---|
| Name | BDBM50593371 |
|---|
| Synonyms: | CHEMBL5189637 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H21ClFN3O |
|---|
| Mol. Mass. | 349.83 |
|---|
| SMILES | Cc1cc(NC(=O)Cc2ccc(F)c(Cl)c2)n(n1)C1CCCCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
