| Reaction Details |
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 | Report a problem with these data |
| Target | Calcium-activated potassium channel subunit alpha-1 |
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| Ligand | BDBM50593373 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2208121 (CHEMBL5121070) |
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| EC50 | >30000±n/a nM |
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| Citation |  Sharma, S; Lesiak, L; Aretz, CD; Du, Y; Kumar, S; Gautam, N; Alnouti, Y; Dhuria, NV; Chhonker, YS; Weaver, CD; Hopkins, CR Discovery, synthesis and biological characterization of a series of RSC Med Chem12:1366-1373 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcium-activated potassium channel subunit alpha-1 |
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| Name: | Calcium-activated potassium channel subunit alpha-1 |
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| Synonyms: | Calcium-activated potassium channel alpha/beta 1 | KCMA1_HUMAN | KCNMA | KCNMA1 | Large conductance calcium-activated potassium channel subfamily M alpha member 1 isoform b | SLO |
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| Type: | PROTEIN |
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| Mol. Mass.: | 137567.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_938830 |
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| Residue: | 1236 |
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| Sequence: | MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSS
VHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCH
CGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVL
VVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKL
WFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKL
VNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYA
KTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLES
VSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVK
IESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSW
NWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNE
MYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLG
FFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRPKMSIYKRMRRACCFDCGRSERD
CSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPSTLSPKKKQRNGGMRNSPN
TSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSG
HVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVS
ILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIG
VLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDD
DPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEEN
ALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRL
RDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSS
KKSSSVHSIPSTANRQNRPKSRESRDKQKYVQEERL
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| BDBM50593373 |
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| n/a |
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| Name | BDBM50593373 |
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| Synonyms: | CHEMBL5182581 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H17Cl2N3O4S |
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| Mol. Mass. | 418.295 |
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| SMILES | Cc1cc(NC(=O)COc2ccc(Cl)cc2Cl)n(n1)C1CCS(=O)(=O)C1 |
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| Structure | 
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