| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Presenilin-1 |
|---|
| Ligand | BDBM50593498 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2208428 (CHEMBL5121377) |
|---|
| IC50 | 0.225000±n/a nM |
|---|
| Citation |  Das, B; Baidya, ATK; Mathew, AT; Yadav, AK; Kumar, R Structural modification aimed for improving solubility of lead compounds in early phase drug discovery. Bioorg Med Chem56:0 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Presenilin-1 |
|---|
| Name: | Presenilin-1 |
|---|
| Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 52657.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P49768 |
|---|
| Residue: | 467 |
|---|
| Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
|
|
|
|---|
| BDBM50593498 |
|---|
| n/a |
|---|
| Name | BDBM50593498 |
|---|
| Synonyms: | CHEMBL5198066 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H18ClF4N3O4S |
|---|
| Mol. Mass. | 519.897 |
|---|
| SMILES | NC(=O)C(CCC(F)(F)F)C(Cc1ccc(cc1F)-c1ncon1)S(=O)(=O)c1ccc(Cl)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
