Reaction Details |
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Target | Carbonic anhydrase 12 |
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Ligand | BDBM50167405 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_302561 (CHEMBL839523) |
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Ki | 5.9±n/a nM |
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Citation | Puccetti, L; Fasolis, G; Vullo, D; Chohan, ZH; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes. Bioorg Med Chem Lett15:3096-101 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 12 |
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Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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BDBM50167405 |
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n/a |
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Name | BDBM50167405 |
Synonyms: | CHEMBL539686 | sulfanilamide derivative |
Type | Small organic molecule |
Emp. Form. | C36H34Cl2N4O8S2Zn |
Mol. Mass. | 851.121 |
SMILES | NS(=O)(=O)c1ccc(CC[N+]2=CC3=COc4ccccc4C3O[Zn]22(Cl)(Cl)OC3C(=COc4ccccc34)C=[N+]2CCc2ccc(cc2)S(N)(=O)=O)cc1 |c:31,42,t:10,12| |
Structure |
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