| Reaction Details |
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 | Report a problem with these data |
| Target | Protein mono-ADP-ribosyltransferase PARP10 |
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| Ligand | BDBM50594006 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2210611 (CHEMBL5123560) |
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| IC50 | 130±n/a nM |
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| Citation |  Nizi, MG; Maksimainen, MM; Murthy, S; Massari, S; Alaviuhkola, J; Lippok, BE; Sowa, ST; Galera-Prat, A; Prunskaite-Hyyryläinen, R; Lüscher, B; Korn, P; Lehtiö, L; Tabarrini, O Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15. Eur J Med Chem237:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein mono-ADP-ribosyltransferase PARP10 |
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| Name: | Protein mono-ADP-ribosyltransferase PARP10 |
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| Synonyms: | 2.4.2.- | 2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 10 | ARTD10 | Human diphtheria toxin-like ADP-ribosyltransferase (ARTD10 or PARP10, L926Y)) | Human diphtheria toxin-like ADP-ribosyltransferase (ARTD10 or PARP10, R931A)) | Human diphtheria toxin-like ADP-ribosyltransferase (ARTD10 or PARP10, S927A)) | PAR10_HUMAN | PARP-10 | PARP10 | Poly [ADP-ribose] polymerase 10 |
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| Type: | n/a |
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| Mol. Mass.: | 109953.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q53GL7 |
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| Residue: | 1025 |
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| Sequence: | MVAMAEAEAGVAVEVRGLPPAVPDELLTLYFENRRRSGGGPVLSWQRLGCGGVLTFREPA
DAERVLAQADHELHGAQLSLRPAPPRAPARLLLQGLPPGTTPQRLEQHVQALLRASGLPV
QPCCALASPRPDRALVQLPKPLSEADVRVLEEQAQNLGLEGTLVSLARVPQARAVRVVGD
GASVDLLLLELYLENERRSGGGPLEDLQRLPGPLGTVASFQQWQVAERVLQQEHRLQGSE
LSLVPHYDILEPEELAENTSGGDHPSTQGPRATKHALLRTGGLVTALQGAGTVTMGSGEE
PGQSGASLRTGPMVQGRGIMTTGSGQEPGQSGTSLRTGPMGSLGQAEQVSSMPMGSLEHE
GLVSLRPVGLQEQEGPMSLGPVGSAGPVETSKGLLGQEGLVEIAMDSPEQEGLVGPMEIT
MGSLEKAGPVSPGCVKLAGQEGLVEMVLLMEPGAMRFLQLYHEDLLAGLGDVALLPLEGP
DMTGFRLCGAQASCQAAEEFLRSLLGSISCHVLCLEHPGSARFLLGPEGQHLLQGLEAQF
QCVFGTERLATATLDTGLEEVDPTEALPVLPGNAHTLWTPDSTGGDQEDVSLEEVRELLA
TLEGLDLDGEDWLPRELEEEGPQEQPEEEVTPGHEEEEPVAPSTVAPRWLEEEAALQLAL
HRSLEPQGQVAEQEEAAALRQALTLSLLEQPPLEAEEPPDGGTDGKAQLVVHSAFEQDVE
ELDRALRAALEVHVQEETVGPWRRTLPAELRARLERCHGVSVALRGDCTILRGFGAHPAR
AARHLVALLAGPWDQSLAFPLAASGPTLAGQTLKGPWNNLERLAENTGEFQEVVRAFYDT
LDAARSSIRVVRVERVSHPLLQQQYELYRERLLQRCERRPVEQVLYHGTTAPAVPDICAH
GFNRSFCGRNATVYGKGVYFARRASLSVQDRYSPPNADGHKAVFVARVLTGDYGQGRRGL
RAPPLRGPGHVLLRYDSAVDCICQPSIFVIFHDTQALPTHLITCEHVPRASPDDPSGLPG
RSPDT
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| BDBM50594006 |
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| n/a |
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| Name | BDBM50594006 |
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| Synonyms: | CHEMBL5192839 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H16N2O3 |
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| Mol. Mass. | 260.2884 |
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| SMILES | O=c1[nH][nH]c(=O)c2cc(OCC3CCCC3)ccc12 |
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| Structure | 
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