| Reaction Details |
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 | Report a problem with these data |
| Target | REST corepressor 1 |
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| Ligand | BDBM50594087 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2210855 (CHEMBL5123804) |
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| Ki | 569±n/a nM |
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| Citation |  Menna, M; Fiorentino, F; Marrocco, B; Lucidi, A; Tomassi, S; Cilli, D; Romanenghi, M; Cassandri, M; Pomella, S; Pezzella, M; Del Bufalo, D; Zeya Ansari, MS; Toma?evi?, N; Mladenovi?, M; Viviano, M; Sbardella, G; Rota, R; Trisciuoglio, D; Minucci, S; Mattevi, A; Rotili, D; Mai, A Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur J Med Chem237:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| REST corepressor 1 |
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| Name: | REST corepressor 1 |
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| Synonyms: | KIAA0071 | Protein CoREST | RCOR | RCOR1 | RCOR1_HUMAN | REST corepressor 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53329.34 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108118 |
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| Residue: | 485 |
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| Sequence: | MPAMVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAAS
AAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDP
AKLARRSQERDNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEK
SLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTR
TKTSVMDRHARKQKREREESEDELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKKEK
HSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNS
ALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQV
KNFFVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLDVR
YASAS
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| BDBM50594087 |
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| n/a |
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| Name | BDBM50594087 |
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| Synonyms: | CHEMBL5189687 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H40N6O2 |
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| Mol. Mass. | 492.6562 |
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| SMILES | COc1cc2nc(NCCCN(C)C)nc(N(C)C3CCN(Cc4ccccc4)CC3)c2cc1OC |
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| Structure | 
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