| Reaction Details |
|---|
 | Report a problem with these data |
| Target | REST corepressor 1 |
|---|
| Ligand | BDBM50594099 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2210855 (CHEMBL5123804) |
|---|
| Ki | 175±n/a nM |
|---|
| Citation |  Menna, M; Fiorentino, F; Marrocco, B; Lucidi, A; Tomassi, S; Cilli, D; Romanenghi, M; Cassandri, M; Pomella, S; Pezzella, M; Del Bufalo, D; Zeya Ansari, MS; Toma?evi?, N; Mladenovi?, M; Viviano, M; Sbardella, G; Rota, R; Trisciuoglio, D; Minucci, S; Mattevi, A; Rotili, D; Mai, A Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur J Med Chem237:0 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| REST corepressor 1 |
|---|
| Name: | REST corepressor 1 |
|---|
| Synonyms: | KIAA0071 | Protein CoREST | RCOR | RCOR1 | RCOR1_HUMAN | REST corepressor 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 53329.34 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_108118 |
|---|
| Residue: | 485 |
|---|
| Sequence: | MPAMVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAAS
AAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDP
AKLARRSQERDNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEK
SLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTR
TKTSVMDRHARKQKREREESEDELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKKEK
HSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNS
ALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQV
KNFFVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLDVR
YASAS
|
|
|
|---|
| BDBM50594099 |
|---|
| n/a |
|---|
| Name | BDBM50594099 |
|---|
| Synonyms: | CHEMBL5186174 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H42N6O2 |
|---|
| Mol. Mass. | 506.6828 |
|---|
| SMILES | CCN(CC)CCCNc1nc(NC2CCN(Cc3ccccc3)CC2)c2cc(OC)c(OC)cc2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
