| Reaction Details |
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 | Report a problem with these data |
| Target | RNA-directed RNA polymerase |
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| Ligand | BDBM50167659 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306492 (CHEMBL827995) |
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| IC50 | 1000±n/a nM |
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| Citation |  Pfefferkorn, JA; Nugent, R; Gross, RJ; Greene, M; Mitchell, MA; Reding, MT; Funk, LA; Anderson, R; Wells, PA; Shelly, JA; Anstadt, R; Finzel, BC; Harris, MS; Kilkuskie, RE; Kopta, LA; Schwende, FJ Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid. Bioorg Med Chem Lett15:2812-8 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RNA-directed RNA polymerase |
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| Name: | RNA-directed RNA polymerase |
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| Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
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| Type: | Protein |
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| Mol. Mass.: | 25173.95 |
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| Organism: | Hepatitis C virus |
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| Description: | Q8JXU8 |
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| Residue: | 229 |
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| Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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| BDBM50167659 |
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| n/a |
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| Name | BDBM50167659 |
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| Synonyms: | CHEMBL191832 | N-{(Z)-2-[4-(2-Bromo-phenoxy)-phenyl]-1-hydrazinocarbonyl-vinyl}-benzamide |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18BrN3O3 |
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| Mol. Mass. | 452.301 |
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| SMILES | NNC(=O)C(\NC(=O)c1ccccc1)=C\c1ccc(Oc2ccccc2Br)cc1 |
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| Structure | 
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