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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 2 | ||
| Ligand | BDBM530621 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2213076 (CHEMBL5126025) | ||
| IC50 | 0.700000±n/a nM | ||
| Citation |  Sabnis, RW Benzimidazolone Derivatives as DGAT2 Inhibitors for Treating Diseases. ACS Med Chem Lett13:1004-1005 (2022) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 2 | |||
| Name: | Diacylglycerol O-acyltransferase 2 | ||
| Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase | ||
| Type: | Multi-pass membrane protein | ||
| Mol. Mass.: | 43848.90 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q96PD7 | ||
| Residue: | 388 | ||
| Sequence: |
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| BDBM530621 | |||
| n/a | |||
| Name | BDBM530621 | ||
| Synonyms: | 1-(5-(difluoromethoxy)-2-fluorophenyl)-3-(3-hydroxy-3-methylbutan-2-yl)-N-(3-methyl-1,1-dioxidothietan-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxamide | WO2022076495, EXAMPLE 65 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H26F3N3O6S | ||
| Mol. Mass. | 541.54 | ||
| SMILES | CC(n1c2cc(ccc2n(-c2cc(OC(F)F)ccc2F)c1=O)C(=O)NC1(C)CS(=O)(=O)C1)C(C)(C)O |(2.68,2.55,;1.65,1.41,;2.13,-.06,;3.59,-.53,;4.92,.24,;6.26,-.53,;6.26,-2.07,;4.92,-2.84,;3.59,-2.07,;2.13,-2.55,;1.65,-4.01,;.14,-4.33,;-.33,-5.8,;-1.84,-6.12,;-2.87,-4.97,;-4.38,-5.29,;-2.39,-3.51,;.7,-6.94,;2.2,-6.62,;2.68,-5.16,;4.19,-4.84,;1.22,-1.3,;-.32,-1.3,;7.59,.24,;7.59,1.78,;8.93,-.53,;10.26,.24,;11.03,-1.1,;9.49,1.57,;10.82,2.34,;10.05,3.67,;12.16,3.11,;11.59,1.01,;.14,1.73,;-.89,.58,;.62,.26,;-.33,3.19,)| | ||
| Structure | 
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