Reaction Details | |||
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Target | Diacylglycerol O-acyltransferase 2 | ||
Ligand | BDBM50594461 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_2213076 (CHEMBL5126025) | ||
IC50 | 1.000000±n/a nM | ||
Citation | Sabnis, RW Benzimidazolone Derivatives as DGAT2 Inhibitors for Treating Diseases. ACS Med Chem Lett13:1004-1005 (2022) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Diacylglycerol O-acyltransferase 2 | |||
Name: | Diacylglycerol O-acyltransferase 2 | ||
Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase | ||
Type: | Multi-pass membrane protein | ||
Mol. Mass.: | 43848.90 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q96PD7 | ||
Residue: | 388 | ||
Sequence: |
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BDBM50594461 | |||
n/a | |||
Name | BDBM50594461 | ||
Synonyms: | CHEMBL5202996 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H28F5N3O6S | ||
Mol. Mass. | 605.574 | ||
SMILES | CC(n1c2cc(C(=O)NC3(C)CCS(=O)(=O)CC3)c(F)cc2n(-c2cc(OC(F)(F)F)ccc2F)c1=O)C(C)(C)O |(2.41,-4.44,;3.43,-3.29,;2.95,-1.83,;1.48,-1.37,;.14,-2.14,;-1.2,-1.37,;-2.53,-2.14,;-2.53,-3.68,;-3.86,-1.37,;-5.2,-2.14,;-5.61,-.65,;-6.53,-1.36,;-7.86,-2.12,;-7.88,-3.66,;-8.66,-4.99,;-9.42,-3.65,;-6.54,-4.43,;-5.2,-3.67,;-1.19,.17,;-2.53,.94,;.13,.94,;1.47,.18,;2.93,.66,;3.4,2.12,;4.91,2.45,;5.38,3.92,;6.88,4.24,;7.92,3.1,;9.42,3.43,;7.45,1.64,;9,2.02,;4.34,5.06,;2.83,4.72,;2.37,3.25,;.86,2.92,;3.85,-.58,;5.39,-.57,;4.93,-3.59,;5.42,-5.06,;5.95,-2.44,;6.41,-3.99,)| | ||
Structure |