| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin receptor type 2 |
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| Ligand | BDBM50594478 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2213082 (CHEMBL5126031) |
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| EC50 | 0.250000±n/a nM |
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| Citation |  Sabnis, RW Novel Macrocyclic Urea Orexin Receptor Agonists for Treating Sleep Disorders. ACS Med Chem Lett13:1010-1011 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin receptor type 2 |
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| Name: | Orexin receptor type 2 |
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| Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
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| Type: | Protein |
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| Mol. Mass.: | 50710.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43614 |
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| Residue: | 444 |
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| Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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| BDBM50594478 |
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| n/a |
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| Name | BDBM50594478 |
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| Synonyms: | CHEMBL5176663 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H34F2N6O4 |
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| Mol. Mass. | 532.5828 |
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| SMILES | CCN1[C@H](C)c2cc(c(OC)cn2)-c2cc3ccnn3c(OCCOCC[C@H](CCC(C)(F)F)NC1=O)n2 |r| |
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| Structure | 
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