| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK3 |
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| Ligand | BDBM50347742 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2214240 (CHEMBL5127372) |
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| IC50 | 9500±n/a nM |
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| Citation |  Tahtouh, T; Durieu, E; Villiers, B; Bruyère, C; Nguyen, TL; Fant, X; Ahn, KH; Khurana, L; Deau, E; Lindberg, MF; Sévère, E; Miege, F; Roche, D; Limanton, E; L'Helgoual'ch, JM; Burgy, G; Guiheneuf, S; Herault, Y; Kendall, DA; Carreaux, F; Bazureau, JP; Meijer, L Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. J Med Chem65:1396-1417 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity protein kinase CLK3 |
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| Name: | Dual specificity protein kinase CLK3 |
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| Synonyms: | CDC-like kinase 3 | CLK3_MOUSE | Clk3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 73855.32 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1502247 |
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| Residue: | 638 |
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| Sequence: | MPVLSARRKRLASTAGPRRGSGPSLAVRWVPPLGPEPSSDRGRAPMRPRGPTCSTTRRGA
GRGPRLLPGPPGRDLHRCRPDPGGAGQSPRVCEFGARAVRPLGRVEPGPPTAASREGAVL
PRAEARAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEG
RLRYPSRREPPPRRSRSRSHDRIPYQRRYREHRDSDTYRCEERSPSFGEDCYGSSRSRHR
RRSRERAPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWL
QERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKD
KENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALR
FLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHT
TIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGP
IPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRM
LEFDPAQRITLAEALLHPFFAGLTPEERSFHSSRNPSR
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| BDBM50347742 |
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| n/a |
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| Name | BDBM50347742 |
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| Synonyms: | CHEMBL1803081 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19N3O3 |
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| Mol. Mass. | 349.3832 |
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| SMILES | CCCNC1=NC(=Cc2ccc3OCOc3c2)C(=O)N1c1ccccc1 |w:7.7,t:4| |
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| Structure | 
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