| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK1 |
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| Ligand | BDBM50594790 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2214241 (CHEMBL5127373) |
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| IC50 | 12±n/a nM |
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| Citation |  Tahtouh, T; Durieu, E; Villiers, B; Bruyère, C; Nguyen, TL; Fant, X; Ahn, KH; Khurana, L; Deau, E; Lindberg, MF; Sévère, E; Miege, F; Roche, D; Limanton, E; L'Helgoual'ch, JM; Burgy, G; Guiheneuf, S; Herault, Y; Kendall, DA; Carreaux, F; Bazureau, JP; Meijer, L Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. J Med Chem65:1396-1417 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity protein kinase CLK1 |
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| Name: | Dual specificity protein kinase CLK1 |
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| Synonyms: | CDC-like kinase 1 | CLK1_MOUSE | Clk | Clk1 | Protein kinase STY | Sty |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57124.52 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1502245 |
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| Residue: | 483 |
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| Sequence: | MRHSKRTYCPDWDERDWDYGTWRSSSSHKRKKRSHSSAREQKRCRYDHSKTTDSYYLESR
SINEKAYHSRRYVDEYRNDYMGYEPGHPYGEPGSRYQMHSSKSSGRSGRSSYKSKHRSRH
HTSQHHSHGKSHRRKRSRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDH
KVGGRRVAVKIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVF
ELLGLSTYDFIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDY
TEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCD
VWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQKTRKRRYFHHDRLDWDE
HSSAGRYVSRRCKPLKEFMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFFYPLK
KHT
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| BDBM50594790 |
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| n/a |
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| Name | BDBM50594790 |
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| Synonyms: | CHEMBL5200518 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25N5O3 |
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| Mol. Mass. | 407.4656 |
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| SMILES | COc1cc(\C=C2/N=C(Nc3ccc(cc3)N3CCN(C)CC3)NC2=O)ccc1O |t:7| |
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| Structure | 
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