| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk2 |
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| Ligand | BDBM50524300 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2214668 (CHEMBL5127800) |
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| IC50 | 8.0±n/a nM |
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| Citation |  Cheng, B; Pan, W; Xing, Y; Xiao, Y; Chen, J; Xu, Z Recent advances in DDR (DNA damage response) inhibitors for cancer therapy. Eur J Med Chem230:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Chk2 |
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| Name: | Serine/threonine-protein kinase Chk2 |
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| Synonyms: | CDS1 | CHEK2 | CHK2 | CHK2_HUMAN | Checkpoint Kinase (Chk2) | RAD53 | Serine/threonine-protein kinase Chek2 | Serine/threonine-protein kinase Chk1/2 |
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| Type: | Protein |
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| Mol. Mass.: | 60908.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O96017 |
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| Residue: | 543 |
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| Sequence: | MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
SSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKS
CEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKR
RPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFER
KTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIV
LELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEE
DCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFIC
LSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEA
LRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCA
AVL
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| BDBM50524300 |
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| n/a |
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| Name | BDBM50524300 |
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| Synonyms: | LY2606368 | Prexasertib | US11564920, Example Prexasertib |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19N7O2 |
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| Mol. Mass. | 365.3892 |
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| SMILES | COc1cccc(OCCCN)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1 |
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| Structure | 
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