Reaction Details |
| Report a problem with these data |
Target | Beta-secretase 1 |
---|
Ligand | BDBM50595066 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2215339 (CHEMBL5128471) |
---|
IC50 | 3000±n/a nM |
---|
Citation | Kumar, N; Kumar, V; Anand, P; Kumar, V; Ranjan Dwivedi, A; Kumar, V Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease. Bioorg Med Chem61:0 (2022) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Beta-secretase 1 |
---|
Name: | Beta-secretase 1 |
Synonyms: | ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1) |
Type: | Protein |
Mol. Mass.: | 55755.10 |
Organism: | Homo sapiens (Human) |
Description: | P56817 |
Residue: | 501 |
Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRQQHDDFADDISLLK
|
|
|
BDBM50595066 |
---|
n/a |
---|
Name | BDBM50595066 |
Synonyms: | CHEMBL5188397 |
Type | Small organic molecule |
Emp. Form. | C16H14N6S2 |
Mol. Mass. | 354.453 |
SMILES | Cc1cc2nc(-c3cnc(N)s3)c(nc2cc1C)-c1cnc(N)s1 |
Structure |
|