| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2A |
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| Ligand | BDBM50169842 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302343 (CHEMBL828927) |
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| Ki | 0.63±n/a nM |
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| Citation |  Fish, LR; Gilligan, MT; Humphries, AC; Ivarsson, M; Ladduwahetty, T; Merchant, KJ; O'Connor, D; Patel, S; Philipps, E; Vargas, HM; Hutson, PH; MacLeod, AM 4-Fluorosulfonylpiperidines: selective 5-HT2A ligands for the treatment of insomnia. Bioorg Med Chem Lett15:3665-9 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 2A |
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| Name: | 5-hydroxytryptamine receptor 2A |
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| Synonyms: | 5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 52852.05 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Rat cortex membranes 5-HT2A receptors. |
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| Residue: | 471 |
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| Sequence: | MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYK
SSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
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| BDBM50169842 |
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| n/a |
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| Name | BDBM50169842 |
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| Synonyms: | 1-(2,4-difluorophenethyl)-4-fluoro-4-(4-fluorophenylsulfonyl)piperidine | 1-[2-(2,4-Difluoro-phenyl)-ethyl]-4-fluoro-4-(4-fluoro-benzenesulfonyl)-piperidine | CHEMBL175832 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19F4NO2S |
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| Mol. Mass. | 401.418 |
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| SMILES | Fc1ccc(cc1)S(=O)(=O)C1(F)CCN(CCc2ccc(F)cc2F)CC1 |
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| Structure | 
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