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TargetMetabotropic glutamate receptor 2
LigandBDBM50153757
Substrate/Competitorn/a
Meas. Tech.ChEMBL_304368
EC50 348±n/a nM
Citation Govek SPBonnefous CHutchinson JHKamenecka TMcQuiston JPracitto RZhao LXGardner MFJames JKDaggett LPRowe BASchaffhauser HBristow LJCampbell UCRodriguez DEVernier JM Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): efficacy in an animal model for schizophrenia. Bioorg Med Chem Lett 15:4068-72 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Metabotropic glutamate receptor 2
Name:Metabotropic glutamate receptor 2
Synonyms:GRM2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | mGluR2 | metabotropic glutamate 2
Type:Enzyme
Mol. Mass.:95584.88
Organism:Homo sapiens (Human)
Description:Q14416
Residue:872
Sequence:
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL
ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA
RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
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  Blast E-value cutoff:
BDBM50153757
n/a
NameBDBM50153757
Synonyms:1-(2-Hydroxy-3-propyl-4-{4-[4-(1H-tetrazol-5-yl)-phenoxy]-butoxy}-phenyl)-ethanone | 1-(2-Hydroxy-3-propyl-4-{4-[4-(2H-tetrazol-5-yl)-phenoxy]-butoxy}-phenyl)-ethanone | CHEMBL182371
TypeSmall organic molecule
Emp. Form.C22H26N4O4
Mol. Mass.410.4662
SMILESCCCc1c(OCCCCOc2ccc(cc2)-c2nnn[nH]2)ccc(C(C)=O)c1O
Structure
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