Reaction Details |
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Target | Melanin-concentrating hormone receptor 1 |
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Ligand | BDBM50170408 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_303115 (CHEMBL829624) |
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Ki | 16±n/a nM |
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Citation | Huang, CQ; Baker, T; Schwarz, D; Fan, J; Heise, CE; Zhang, M; Goodfellow, VS; Markison, S; Gogas, KR; Chen, T; Wang, XC; Zhu, YF 1-(4-Amino-phenyl)-pyrrolidin-3-yl-amine and 6-(3-amino-pyrrolidin-1-yl)-pyridin-3-yl-amine derivatives as melanin-concentrating hormone receptor-1 antagonists. Bioorg Med Chem Lett15:3701-6 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Melanin-concentrating hormone receptor 1 |
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Name: | Melanin-concentrating hormone receptor 1 |
Synonyms: | G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 45976.27 |
Organism: | Homo sapiens (Human) |
Description: | Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays. |
Residue: | 422 |
Sequence: | MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARL
WEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTIC
LLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHF
GETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALS
FISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI
LQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVY
LYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESK
GT
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BDBM50170408 |
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n/a |
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Name | BDBM50170408 |
Synonyms: | CHEMBL178250 | N-[4-(3-Dimethylamino-pyrrolidin-1-yl)-phenyl]-6-(4-methoxy-phenyl)-nicotinamide |
Type | Small organic molecule |
Emp. Form. | C25H28N4O2 |
Mol. Mass. | 416.5154 |
SMILES | COc1ccc(cc1)-c1ccc(cn1)C(=O)Nc1ccc(cc1)N1CCC(C1)N(C)C |
Structure |
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