Reaction Details |
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Target | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 |
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Ligand | BDBM50170748 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_302233 (CHEMBL827006) |
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Kd | 540000±n/a nM |
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Citation | Smet, C; Duckert, JF; Wieruszeski, JM; Landrieu, I; Buée, L; Lippens, G; Déprez, B Control of protein-protein interactions: structure-based discovery of low molecular weight inhibitors of the interactions between Pin1 WW domain and phosphopeptides. J Med Chem48:4815-23 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 |
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Name: | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 |
Synonyms: | PIN1 | PIN1_HUMAN | PPIase Pin1 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 |
Type: | PROTEIN |
Mol. Mass.: | 18248.11 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1502595 |
Residue: | 163 |
Sequence: | MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHL
LVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARG
DLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE
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BDBM50170748 |
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n/a |
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Name | BDBM50170748 |
Synonyms: | CHEMBL366302 | [(S)-1-((S)-2-Carbamoyl-pyrrolidine-1-carbonyl)-5-(2-hydroxy-3,4-dioxo-cyclobut-1-enylamino)-pentyl]-carbamic acid 9H-fluoren-9-ylmethyl ester |
Type | Small organic molecule |
Emp. Form. | C30H32N4O7 |
Mol. Mass. | 560.5977 |
SMILES | NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNc1c(O)c(=O)c1=O)NC(=O)OCC1c2ccccc2-c2ccccc12 |
Structure |
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