| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM50595851 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2218136 (CHEMBL5131268) |
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| EC50 | 955±n/a nM |
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| Citation |  Stefanucci, A; Della Valle, A; Scioli, G; Marinaccio, L; Pieretti, S; Minosi, P; Szucs, E; Benyhe, S; Masci, D; Tanguturi, P; Chou, K; Barlow, D; Houseknecht, K; Streicher, JM; Mollica, A Discovery of ? Opioid Receptor (KOR)-Selective d-Tetrapeptides with Improved ACS Med Chem Lett13:1707-1714 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42744.99 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | P41144 |
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| Residue: | 380 |
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| Sequence: | MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRV
RNTVQDPAYMRNVDGVNKPV
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| BDBM50595851 |
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| n/a |
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| Name | BDBM50595851 |
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| Synonyms: | CHEMBL5192735 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H43FN8O4 |
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| Mol. Mass. | 598.712 |
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| SMILES | CCCC[C@@H](NC(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@H](N)Cc1ccccc1)C(=O)N[C@H](CCCNC(N)=N)C(N)=O |r| |
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| Structure | 
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