| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Caspase-3 |
|---|
| Ligand | BDBM50171432 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_304239 (CHEMBL877120) |
|---|
| EC50 | 750±n/a nM |
|---|
| Citation |  Zhang, HZ; Kasibhatla, S; Kuemmerle, J; Kemnitzer, W; Ollis-Mason, K; Qiu, L; Crogan-Grundy, C; Tseng, B; Drewe, J; Cai, SX Discovery and structure-activity relationship of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers and potential anticancer agents. J Med Chem48:5215-23 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Caspase-3 |
|---|
| Name: | Caspase-3 |
|---|
| Synonyms: | Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein |
|---|
| Type: | Hydrolase; heterotetramer of two heterodimers |
|---|
| Mol. Mass.: | 31607.55 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 277 |
|---|
| Sequence: | MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
|
|
|
|---|
| BDBM50171432 |
|---|
| n/a |
|---|
| Name | BDBM50171432 |
|---|
| Synonyms: | 2-Chloro-5-[5-(3-chloro-thiophen-2-yl)-[1,2,4]oxadiazol-3-yl]-pyridine | CHEMBL189946 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H5Cl2N3OS |
|---|
| Mol. Mass. | 298.148 |
|---|
| SMILES | Clc1ccsc1-c1nc(no1)-c1ccc(Cl)nc1 |
|---|
| Structure | 
|
|---|
Search and Browse
