Reaction Details |
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Target | Thromboxane A2 receptor |
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Ligand | BDBM50171475 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_303672 (CHEMBL830433) |
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Ki | 4.3±n/a nM |
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Citation | Ohno, M; Miyamoto, M; Hoshi, K; Takeda, T; Yamada, N; Ohtake, A Development of dual-acting benzofurans for thromboxane A2 receptor antagonist and prostacyclin receptor agonist: synthesis, structure-activity relationship, and evaluation of benzofuran derivatives. J Med Chem48:5279-94 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Thromboxane A2 receptor |
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Name: | Thromboxane A2 receptor |
Synonyms: | Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta |
Type: | Enyzme |
Mol. Mass.: | 37445.28 |
Organism: | Homo sapiens (Human) |
Description: | P21731 |
Residue: | 343 |
Sequence: | MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTR
SSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPL
LLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPG
SWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSE
VEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWN
QILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
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BDBM50171475 |
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n/a |
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Name | BDBM50171475 |
Synonyms: | CHEMBL190288 | {3-[2-(Diphenyl-ethanesulfonyl)-ethyl]-2-hydroxymethyl-benzofuran-7-yloxy}-acetic acid |
Type | Small organic molecule |
Emp. Form. | C27H26O7S |
Mol. Mass. | 494.556 |
SMILES | CC(c1ccccc1)(c1ccccc1)S(=O)(=O)CCc1c(CO)oc2c(OCC(O)=O)cccc12 |
Structure |
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