| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Blk |
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| Ligand | BDBM259407 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2220477 (CHEMBL5133811) |
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| Kd | 30000±n/a nM |
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| Citation |  Ma, B; Metrick, CM; Gu, C; Hoemberger, M; Bajrami, B; Bame, E; Huang, J; Mingueneau, M; Murugan, P; Santoro, JC; Tang, H; Wang, T; Hopkins, BT Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors. Bioorg Med Chem Lett60:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Blk |
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| Name: | Tyrosine-protein kinase Blk |
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| Synonyms: | B lymphoid tyrosine kinase | BLK | BLK_HUMAN | SRC | Tyrosine-protein kinase BLK (BLK) | p55-Blk |
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| Type: | Protein |
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| Mol. Mass.: | 57711.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51451 |
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| Residue: | 505 |
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| Sequence: | MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDK
HFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLE
MERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIR
CLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQS
LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY
AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD
LRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWS
FGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEER
PTFEFLQSVLEDFYTATERQYELQP
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| BDBM259407 |
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| n/a |
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| Name | BDBM259407 |
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| Synonyms: | US10457647, Example 6 | US11180460, Example 6 | US11673868, Example 6 | US9512084, 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H27F2N5O3 |
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| Mol. Mass. | 507.5318 |
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| SMILES | CN(CCOc1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(cc2F)C2CC2)c1C)C(=O)C=C |
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| Structure | 
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