| Reaction Details |
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 | Report a problem with these data |
| Target | Cytoplasmic tyrosine-protein kinase BMX |
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| Ligand | BDBM50175583 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2220478 (CHEMBL5133812) |
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| Kd | 19±n/a nM |
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| Citation |  Ma, B; Metrick, CM; Gu, C; Hoemberger, M; Bajrami, B; Bame, E; Huang, J; Mingueneau, M; Murugan, P; Santoro, JC; Tang, H; Wang, T; Hopkins, BT Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors. Bioorg Med Chem Lett60:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytoplasmic tyrosine-protein kinase BMX |
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| Name: | Cytoplasmic tyrosine-protein kinase BMX |
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| Synonyms: | BMX | BMX non-receptor tyrosine kinase | BMX_HUMAN | Bone marrow tyrosine kinase gene in chromosome X protein | Cytoplasmic tyrosine-protein kinase BMX (BMX) | ETK | Epithelial and endothelial tyrosine kinase | NTK38 | Tyrosine Kinase BMX | Tyrosine-protein kinase BMX/ETK |
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| Type: | Tyrosine-protein kinase |
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| Mol. Mass.: | 78030.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51813 |
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| Residue: | 675 |
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| Sequence: | MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI
RCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKY
HSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVL
KMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDF
PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN
ISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLY
LAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLL
KELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCS
KEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAAR
NCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGI
LMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQ
QLLSSIEPLREKDKH
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| BDBM50175583 |
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| n/a |
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| Name | BDBM50175583 |
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| Synonyms: | ACP-196 | Acalabrutinib | US10239883, Example 6 | US10793576, Example ACP-196 | US10919899, ACP-196 | US10934296, Example 6 | US11420975, Acalabrutinlb | US9758524, Example 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H23N7O2 |
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| Mol. Mass. | 465.5065 |
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| SMILES | [H][C@]1(CCCN1C(=O)C#CC)c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12 |r| |
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| Structure | 
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