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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Thyroid hormone receptor beta | ||
| Ligand | BDBM50171799 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_321321 (CHEMBL882591) | ||
| IC50 | 7.2±n/a nM | ||
| Citation |  Hangeland, JJ; Friends, TJ; Doweyko, AM; Mellström, K; Sandberg, J; Grynfarb, M; Ryono, DE A new class of high affinity thyromimetics containing a phenyl-naphthylene core. Bioorg Med Chem Lett15:4579-84 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Thyroid hormone receptor beta | |||
| Name: | Thyroid hormone receptor beta | ||
| Synonyms: | ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta | ||
| Type: | Receptor | ||
| Mol. Mass.: | 52793.62 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1. | ||
| Residue: | 461 | ||
| Sequence: |
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| BDBM50171799 | |||
| n/a | |||
| Name | BDBM50171799 | ||
| Synonyms: | CHEMBL193615 | [3,5-Dichloro-4-(6-hydroxy-5-methyl-naphthalen-1-yl)-phenyl]-carbamic acid | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H13Cl2NO3 | ||
| Mol. Mass. | 362.207 | ||
| SMILES | Cc1c(O)ccc2c(cccc12)-c1c(Cl)cc(NC(O)=O)cc1Cl |(.52,-3.25,;1.87,-2.48,;1.87,-.93,;.54,-.17,;3.2,-.16,;4.53,-.93,;4.53,-2.48,;5.86,-3.25,;5.86,-4.78,;4.53,-5.56,;3.2,-4.79,;3.2,-3.25,;7.19,-2.47,;7.19,-.93,;5.86,-.16,;8.52,-.16,;9.85,-.92,;11.2,-.15,;12.53,-.92,;12.54,-2.46,;13.87,-.14,;9.87,-2.46,;8.52,-3.24,;8.52,-4.78,)| | ||
| Structure | 
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