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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Thyroid hormone receptor beta | ||
| Ligand | BDBM50171808 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_321321 (CHEMBL882591) | ||
| IC50 | 0.3±n/a nM | ||
| Citation |  Hangeland, JJ; Friends, TJ; Doweyko, AM; Mellström, K; Sandberg, J; Grynfarb, M; Ryono, DE A new class of high affinity thyromimetics containing a phenyl-naphthylene core. Bioorg Med Chem Lett15:4579-84 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Thyroid hormone receptor beta | |||
| Name: | Thyroid hormone receptor beta | ||
| Synonyms: | ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta | ||
| Type: | Receptor | ||
| Mol. Mass.: | 52793.62 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1. | ||
| Residue: | 461 | ||
| Sequence: |
| ||
| BDBM50171808 | |||
| n/a | |||
| Name | BDBM50171808 | ||
| Synonyms: | CHEMBL194242 | N-[4-(5-Bromo-6-hydroxy-naphthalen-1-yl)-3,5-dichloro-phenyl]-malonamic acid | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H12BrCl2NO4 | ||
| Mol. Mass. | 469.113 | ||
| SMILES | OC(=O)CC(=O)Nc1cc(Cl)c(c(Cl)c1)-c1cccc2c(Br)c(O)ccc12 |(13.88,-4.76,;13.87,-3.22,;15.2,-2.45,;12.54,-2.46,;12.53,-.92,;13.87,-.14,;11.2,-.15,;9.85,-.92,;9.87,-2.46,;8.52,-3.24,;8.52,-4.78,;7.19,-2.47,;7.19,-.93,;5.86,-.16,;8.52,-.16,;5.86,-3.25,;5.86,-4.78,;4.53,-5.56,;3.2,-4.79,;3.2,-3.25,;1.87,-2.48,;.52,-3.25,;1.87,-.93,;.54,-.17,;3.2,-.16,;4.53,-.93,;4.53,-2.48,)| | ||
| Structure | 
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