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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Thyroid hormone receptor alpha | ||
| Ligand | BDBM50171802 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_321327 (CHEMBL880611) | ||
| IC50 | 14±n/a nM | ||
| Citation |  Hangeland, JJ; Friends, TJ; Doweyko, AM; Mellström, K; Sandberg, J; Grynfarb, M; Ryono, DE A new class of high affinity thyromimetics containing a phenyl-naphthylene core. Bioorg Med Chem Lett15:4579-84 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Thyroid hormone receptor alpha | |||
| Name: | Thyroid hormone receptor alpha | ||
| Synonyms: | C-erbA-alpha | EAR-7 | EAR7 | ERBA1 | NR1A1 | Nuclear receptor subfamily 1 group A member 1 | THA_HUMAN | THRA | THRA1 | THRA2 | Thyroid Hormone Receptor (TR-alpha) | Thyroid hormone receptor | Thyroid hormone receptor alpha | Thyroid hormone receptor apha | c-erbA-1 | ||
| Type: | Receptor | ||
| Mol. Mass.: | 54818.00 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRalpha 1. | ||
| Residue: | 490 | ||
| Sequence: |
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| BDBM50171802 | |||
| n/a | |||
| Name | BDBM50171802 | ||
| Synonyms: | CHEMBL196642 | N-[3,5-Dichloro-4-(5-isopropyl-6-methoxy-naphthalen-1-yl)-phenyl]-malonamic acid | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H21Cl2NO4 | ||
| Mol. Mass. | 446.323 | ||
| SMILES | COc1ccc2c(cccc2c1C(C)C)-c1c(Cl)cc(NC(=O)CC(O)=O)cc1Cl |(1.71,1.66,;1.71,.12,;3.04,-.65,;4.37,.13,;5.72,-.64,;5.72,-2.19,;7.05,-2.96,;7.05,-4.49,;5.7,-5.27,;4.37,-4.5,;4.37,-2.96,;3.04,-2.19,;1.71,-2.96,;.38,-2.19,;1.71,-4.5,;8.38,-2.18,;9.71,-2.95,;9.71,-4.49,;11.04,-2.18,;11.04,-.64,;12.37,.14,;13.7,-.63,;15.05,.16,;13.72,-2.17,;15.06,-2.92,;15.06,-4.46,;16.39,-2.15,;9.71,.13,;8.38,-.64,;7.05,.13,)| | ||
| Structure | 
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