Reaction Details |
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Target | Cytochrome P450 2C19 |
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Ligand | BDBM50172459 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_322416 (CHEMBL873538) |
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IC50 | 35000±n/a nM |
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Citation | Peretto, I; Radaelli, S; Parini, C; Zandi, M; Raveglia, LF; Dondio, G; Fontanella, L; Misiano, P; Bigogno, C; Rizzi, A; Riccardi, B; Biscaioli, M; Marchetti, S; Puccini, P; Catinella, S; Rondelli, I; Cenacchi, V; Bolzoni, PT; Caruso, P; Villetti, G; Facchinetti, F; Del Giudice, E; Moretto, N; Imbimbo, BP Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. J Med Chem48:5705-20 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 2C19 |
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Name: | Cytochrome P450 2C19 |
Synonyms: | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | CP2CJ_HUMAN | CYP2C19 | CYPIIC17 | CYPIIC19 | Cytochrome P450 2C19 (CYP2C19) | Cytochrome P450 2C19 [I331V] | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | P450-11A | P450-254C |
Type: | Enzyme |
Mol. Mass.: | 55935.47 |
Organism: | Homo sapiens (Human) |
Description: | P33261 |
Residue: | 490 |
Sequence: | MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI
YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM
ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYID
LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK
KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP
PFYQLCFIPV
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BDBM50172459 |
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n/a |
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Name | BDBM50172459 |
Synonyms: | 1-(2-Fluoro-4''-hydroxy-[1,1';4',1'']terphenyl-4-yl)-cyclopropanecarboxylic acid | CHEMBL196947 |
Type | Small organic molecule |
Emp. Form. | C22H17FO3 |
Mol. Mass. | 348.367 |
SMILES | OC(=O)C1(CC1)c1ccc(c(F)c1)-c1ccc(cc1)-c1ccc(O)cc1 |
Structure |
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