| Reaction Details |
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 | Report a problem with these data |
| Target | Sigma non-opioid intracellular receptor 1 |
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| Ligand | BDBM50172874 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321541 (CHEMBL881479) |
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| pH | 7.5±n/a |
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| IC50 | 2.9±n/a nM |
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| Comments | extracted |
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| Citation |  Cazenave Gassiot, A; Charton, J; Girault-Mizzi, S; Gilleron, P; Debreu-Fontaine, MA; Sergheraert, C; Melnyk, P Synthesis and pharmacological evaluation of Tic-hydantoin derivatives as selective sigma1 ligands. Part 2. Bioorg Med Chem Lett15:4828-32 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sigma non-opioid intracellular receptor 1 |
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| Name: | Sigma non-opioid intracellular receptor 1 |
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| Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 25124.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99720 |
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| Residue: | 223 |
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| Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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| BDBM50172874 |
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| n/a |
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| Name | BDBM50172874 |
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| Synonyms: | (S)-2-{2-[Methyl-(5-phenyl-pentyl)-amino]-ethyl}-10,10a-dihydro-5H-imidazo[1,5-b]isoquinoline-1,3-dione | CHEMBL194738 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H31N3O2 |
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| Mol. Mass. | 405.5325 |
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| SMILES | CN(CCCCCc1ccccc1)CCn1c(O)c2Cc3ccccc3Cn2c1=O |
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| Structure | 
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