Reaction Details |
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Target | Sigma non-opioid intracellular receptor 1 |
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Ligand | BDBM50172884 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_321527 (CHEMBL880587) |
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pH | 7.5±n/a |
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Temperature | 295.15±n/a K |
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IC50 | 2.4±n/a nM |
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Comments | extracted |
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Citation | Cazenave Gassiot, A; Charton, J; Girault-Mizzi, S; Gilleron, P; Debreu-Fontaine, MA; Sergheraert, C; Melnyk, P Synthesis and pharmacological evaluation of Tic-hydantoin derivatives as selective sigma1 ligands. Part 2. Bioorg Med Chem Lett15:4828-32 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sigma non-opioid intracellular receptor 1 |
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Name: | Sigma non-opioid intracellular receptor 1 |
Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 25124.85 |
Organism: | Homo sapiens (Human) |
Description: | Q99720 |
Residue: | 223 |
Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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BDBM50172884 |
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n/a |
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Name | BDBM50172884 |
Synonyms: | (S)-2-(1-Benzyl-piperidin-4-yl)-10,10a-dihydro-5H-imidazo[1,5-b]isoquinoline-1,3-dione | CHEMBL193699 |
Type | Small organic molecule |
Emp. Form. | C23H25N3O2 |
Mol. Mass. | 375.4635 |
SMILES | Oc1c2Cc3ccccc3Cn2c(=O)n1C1CCN(Cc2ccccc2)CC1 |
Structure |
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