| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A1 |
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| Ligand | BDBM50173196 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_320961 (CHEMBL885368) |
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| Ki | >250±n/a nM |
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| Citation |  Dowling, JE; Vessels, JT; Haque, S; Chang, HX; van Vloten, K; Kumaravel, G; Engber, T; Jin, X; Phadke, D; Wang, J; Ayyub, E; Petter, RC Synthesis of [1,2,4]triazolo[1,5-a]pyrazines as adenosine A2A receptor antagonists. Bioorg Med Chem Lett15:4809-13 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A1 |
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| Name: | Adenosine receptor A1 |
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| Synonyms: | AA1R_RAT | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | Adenosine A1 receptor (A1) | Adenosine receptor | Adenosine receptors A1 | Adora1 |
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| Type: | Protein |
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| Mol. Mass.: | 36704.13 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 326 |
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| Sequence: | MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVT
QRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFL
KIWNDHFRCQPKPPIDEDLPEEKAED
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| BDBM50173196 |
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| n/a |
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| Name | BDBM50173196 |
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| Synonyms: | CHEMBL194244 | [3-(8-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-phenyl]-(4-benzyl-piperazin-1-yl)-methanone |
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| Type | Small organic molecule |
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| Emp. Form. | C27H25N7O2 |
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| Mol. Mass. | 479.5331 |
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| SMILES | Nc1nc(cn2nc(nc12)-c1ccco1)-c1cccc(c1)C(=O)N1CCN(Cc2ccccc2)CC1 |
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| Structure | 
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