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TargetSodium-dependent dopamine transporter
LigandBDBM50174848
Substrate/Competitorn/a
Meas. Tech.ChEMBL_326652 (CHEMBL870557)
IC50 543±n/a nM
Citation Krunic, A; Mariappan, SV; Reith, ME; Dunn, WJ Synthesis and monoamine transporter affinity of 3-aryl substituted trop-2-enes. Bioorg Med Chem Lett15:5488-93 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sodium-dependent dopamine transporter
Name:Sodium-dependent dopamine transporter
Synonyms:DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3
Type:Multi-pass membrane protein
Mol. Mass.:68497.11
Organism:Homo sapiens (Human)
Description:Q01959
Residue:620
Sequence:
MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50174848
n/a
NameBDBM50174848
Synonyms:3-(9H-fluoren-9-yl)-8-methyl-8-aza-bicyclo[3.2.1]octan-3-ol | CHEMBL382955
TypeSmall organic molecule
Emp. Form.C21H23NO
Mol. Mass.305.4134
SMILESCN1C2CCC1CC(O)(C2)C1c2ccccc2-c2ccccc12 |TLB:0:1:7.9.6:3.4,10:7:1:3.4,THB:8:7:1:3.4|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: