| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-mannosidase |
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| Ligand | BDBM50016703 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2226835 (CHEMBL5140348) |
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| IC50 | 474000±n/a nM |
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| Citation |  Wang, JZ; Shimadate, Y; Kise, M; Kato, A; Jia, YM; Li, YX; Fleet, GWJ; Yu, CY trans, trans-2-C-Aryl-3,4-dihydroxypyrrolidines as potent and selective ?-glucosidase inhibitors: Pharmacological chaperones for Gaucher disease. Eur J Med Chem238:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-mannosidase |
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| Name: | Alpha-mannosidase |
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| Synonyms: | Alpha-mannosidase | Alpha-mannosidase, heavy subunit | Alpha-mannosidase, light subunit | JBM | Jbalpha-man | MANA_CANEN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 108565.93 |
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| Organism: | Canavalia ensiformis |
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| Description: | ChEMBL_109557 |
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| Residue: | 959 |
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| Sequence: | MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVENVLDSVVMSLQ
RDPNRKFVFGEMAFFHRWWLEQTPETKELKLVKAGQLEFVNGGWCMHDEATTHYIDMIDH
TTLGHRFLQEQFNKIPRAGWQIDPFGHSAVQGYLLGAELGFDSVHFARIDYQDREKRKGE
KSLEVVWRGSKTFGSSAQIFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERV
QNFLDAALTQAKLTRTNHLMWTMGDDFQYQYAESWFKQMDKLLHHVNKDGRVNALYSTPS
LYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRMLSGYYLATRHSGFFAGKKSTK
YHAFDLADALGIAQHHDAVSGTAKQHTTNDYAKRLALGASKAEAVVSSSLACLTSKQSAD
QCSAPASAFSQCHLFNISYCPPTESSLPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVV
KDSSGNKLEVQYVEMDDVTANLRSFYVKYWSLFKASVPPLGWSTYFISEATGKGTRNALT
LSQKGETLNIGPGDLKMSFSSLTGQLKRMYNSKTGVDLPIQQNYLWYESSEGDFSDYQAS
GAYLFRPNGQPPPHTVSRSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTI
GPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLEVTQPVAGNYY
PLNLGLYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRRTLRDDGRGVGEPLDEQVCMN
KEYTCEGLTVRGNYYLSIHKPAGGSRWRRTTGQEIYSPMLLAFTQENMENWKSSHSTKAY
AMDPNYSLPPSVALITLEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKLEE
LREVSLSANQEKSEMKKMKWSVEGDNEQEPQAVRGGPVSNADFVVELGPMEIRTFLLQF
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| BDBM50016703 |
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| n/a |
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| Name | BDBM50016703 |
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| Synonyms: | 2-Hydroxymethyl-pyrrolidine-3,4-diol | BDBM50031485 | CHEMBL80254 | Imino-D-Arabinitol |
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| Type | Small organic molecule |
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| Emp. Form. | C5H11NO3 |
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| Mol. Mass. | 133.1457 |
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| SMILES | OC[C@H]1NC[C@@H](O)[C@@H]1O |r| |
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| Structure | 
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