| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50175833 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_327753 (CHEMBL861794) |
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| Ki | 0.4±n/a nM |
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| Citation |  Vaccaro, WD; Sher, R; Berlin, M; Shih, NY; Aslanian, R; Schwerdt, JH; McCormick, KD; Piwinski, JJ; West, RE; Anthes, JC; Williams, SM; Wu, RL; She, HS; Rivelli, MA; Mutter, JC; Corboz, MR; Hey, JA; Favreau, L Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffold. Bioorg Med Chem Lett16:395-9 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | HISTAMINE H3 | HRH3 | HRH3_CAVPO | Histamine H3 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48753.61 |
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| Organism: | GUINEA PIG |
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| Description: | HISTAMINE H3 HRH3 GUINEA PIG::Q9JI35 |
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| Residue: | 445 |
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| Sequence: | MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAF
VADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCT
SSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSG
GSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGARE
AGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHSSLEHCWK
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| BDBM50175833 |
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| n/a |
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| Name | BDBM50175833 |
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| Synonyms: | 3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(4-chlorophenyl)propanamide | CHEMBL371730 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H23ClN4O |
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| Mol. Mass. | 346.854 |
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| SMILES | Clc1ccc(NC(=O)CCN2CCC(Cc3cnc[nH]3)CC2)cc1 |
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| Structure | 
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