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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Epidermal growth factor receptor | ||
| Ligand | BDBM50599334 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2229997 (CHEMBL5143769) | ||
| IC50 | 48±n/a nM | ||
| Citation |  Shaikh, M; Shinde, Y; Pawara, R; Noolvi, M; Surana, S; Ahmad, I; Patel, H Emerging Approaches to Overcome Acquired Drug Resistance Obstacles to Osimertinib in Non-Small-Cell Lung Cancer. J Med Chem65:1008-1046 (2022) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Epidermal growth factor receptor | |||
| Name: | Epidermal growth factor receptor | ||
| Synonyms: | EGF Receptor Substrate | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal Growth Factor Receptor Tyrosine Kinase | Epidermal Growth Factor Receptor erbB-1 | Epidermal Growth Factor Receptor, ErbB-1 | Epidermal growth factor receptor (EGFR) | Epidermal growth factor receptor (HER1) | HER1 | Protein-Tyrosine Kinase Erbb-1 | Proto-oncogene c-ErbB-1 | Receptor tyrosine-protein kinase ErbB-1 | Tyrosine-Protein Kinase ErbB-1 | ||
| Type: | Receptor Kinase Domain | ||
| Mol. Mass.: | 134279.59 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P00533 | ||
| Residue: | 1210 | ||
| Sequence: |
| ||
| BDBM50599334 | |||
| n/a | |||
| Name | BDBM50599334 | ||
| Synonyms: | CHEMBL5200385 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C35H40ClN5O2 | ||
| Mol. Mass. | 598.177 | ||
| SMILES | CN1CCN(CC1)c1ccc(Nc2ccc3cc(-c4ccccc4Cl)c(=O)n([C@H]4CC[C@@H](CC4)NC(C)=O)c3c2)cc1C |r,wU:31.36,wD:28.29,(-4,-8.09,;-4,-6.55,;-2.67,-5.77,;-2.67,-4.24,;-4,-3.46,;-5.34,-4.24,;-5.34,-5.77,;-4,-1.92,;-2.67,-1.15,;-2.67,.38,;-4,1.15,;-4,2.69,;-2.67,3.46,;-2.67,5.01,;-1.33,5.78,;-0,5.01,;1.33,5.78,;2.66,5.01,;4,5.78,;4,7.32,;5.33,8.09,;6.66,7.31,;6.66,5.78,;5.34,5.01,;5.34,3.46,;2.66,3.47,;4,2.7,;1.33,2.7,;1.33,1.16,;-0,.39,;-0,-1.15,;1.33,-1.92,;2.66,-1.15,;2.66,.39,;1.33,-3.46,;2.66,-4.23,;2.66,-5.77,;4,-3.46,;-0,3.47,;-1.33,2.7,;-5.34,.38,;-5.33,-1.16,;-6.66,-1.93,)| | ||
| Structure | 
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