Reaction Details |
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Target | N-lysine methyltransferase SMYD2 |
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Ligand | BDBM50599376 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2230265 (CHEMBL5144037) |
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IC50 | 3.0±n/a nM |
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Citation | Dhorma, LP; Teli, MK; Nangunuri, BG; Venkanna, A; Ragam, R; Maturi, A; Mirzaei, A; Vo, DK; Maeng, HJ; Kim, MH Positioning of an unprecedented 1,5-oxaza spiroquinone scaffold into SMYD2 inhibitors in epigenetic space. Eur J Med Chem227:0 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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N-lysine methyltransferase SMYD2 |
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Name: | N-lysine methyltransferase SMYD2 |
Synonyms: | HSKM-B | Histone methyltransferase SMYD2 | KMT3C | Lysine N-methyltransferase 3C | N-lysine methyltransferase SMYD2 | SET and MYND domain-containing protein 2 | SET and MYND domain-containing protein 2 (SMYD2) | SMYD2 | SMYD2_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 49689.57 |
Organism: | Homo sapiens (Human) |
Description: | Q9NRG4 |
Residue: | 433 |
Sequence: | MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKE
GLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHP
ERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLGFPDNDSLVVLFAQVN
CNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSY
IDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARN
VIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGAL
QYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDH
PYISEIKQEIESH
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BDBM50599376 |
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n/a |
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Name | BDBM50599376 |
Synonyms: | CHEMBL3819011 |
Type | Small organic molecule |
Emp. Form. | C29H38Cl2N4O5 |
Mol. Mass. | 593.542 |
SMILES | O[C@@H](CNCCN(C1CCCCC1)C(=O)CCNCCc1ccc(Cl)c(Cl)c1)c1ccc(O)c2NC(=O)COc12 |r| |
Structure |
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